Article
Genetic evidence for the multi-step progression of mixed glandular-neuroendocrine gastric carcinomas.
Virchows Archiv : an international journal of pathology - 1 Jan 2002
Kim Kyoung-Mee, Kim Min-Joo, Cho Bo-Kyoung, Choi Sang-Wook, Rhyu Mun-Gan
Abstract excerpt
A mixed glandular-neuroendocrine gastric carcinoma shows discrete, juxtaposed areas of adenocarcinoma and neuroendocrine carcinoma. In order to gain insight into the genetic events and clonality associated with the dual differentiation of a mixed gastric carcinoma, eight cases (two true composite and six neuroendocrine-dominant carcinomas) were examined by analyzing the genome-wide loss of heterozygosity (LOH)....
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