Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A yeast sterol auxotroph (erg25) is rescued by addition of azole antifungals and reduced levels of heme.

Proceedings of the National Academy of Sciences of the United States of America - 14 Oct 1997

Gachotte D, Pierson C A, Lees N D, Barbuch R, Koegel C, Bard M

Abstract excerpt

Genetic disruption of the Saccharomyces cerevisiae C-4 sterol methyl oxidase ERG25 gene leads to sterol auxotrophy. We have characterized a suppression system that requires two mutations to restore viability to this disrupted strain. One suppressor mutation is erg11, which is blocked in 14alpha-demethylation of lanosterol and is itself an auxotroph. The second suppressor mutation required is either slu1 or slu2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antifungal Agents
Share to Genes, Fungal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genotype

Share to Mixed Function Oxygenases

Share to Mutation

Share to Saccharomyces cerevisiae

Share to Suppression, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 9326581
DOI: 10.1073/pnas.94.21.11173
PMCID: PMC23406

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A yeast sterol auxotroph (erg25) is rescued by addition of azole antifungals and reduced levels of heme.PMID 9326581Read ↗

Sterol synthesis and viability of erg11 (cytochrome P450 lanosterol demethylase) mutations in Saccharomyces cerevisiae and Candida albicans.Semantic proximity Read ↗

The sterol C-24 methyltransferase encoding gene, erg6, is essential for viability of Aspergillus speciesSemantic proximity Read ↗

Sterol uptake in Candida glabrata: rescue of sterol auxotrophic strains.Semantic proximity Read ↗

Erg251 has complex and pleiotropic effects on sterol composition, azole susceptibility, filamentation, and stress response phenotypes.Semantic proximity Read ↗

Metabolic control of antifungal drug resistance.Semantic proximity Read ↗

Sequencing, disruption, and characterization of the Candida albicans sterol methyltransferase (ERG6) gene: drug susceptibility studies in erg6 mutants.Semantic proximity Read ↗

Overexpression or Deletion of Ergosterol Biosynthesis Genes Alters Doubling Time, Response to Stress Agents, and Drug Susceptibility in Saccharomyces cerevisiaeSemantic proximity Read ↗

Alternative ergosterol biosynthetic pathways confer antifungal drug resistance in the human pathogens within the <i>Mucor</i> species complexSemantic proximity Read ↗

An expanded toolkit of drug resistance cassettes for Candida glabrata , Candida auris , and Candida albicans leads to new insights into the ergosterol pathwaySemantic proximity Read ↗

Erg251 has complex and pleiotropic effects on azole susceptibility, filamentation, and stress response phenotypesSemantic proximity Read ↗

A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B.Semantic proximity Read ↗

Candida glabrata erg1 mutant with increased sensitivity to azoles and to low oxygen tension.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.