Metabolic control of antifungal drug resistance.

doi:10.1016/j.fgb.2009.07.004

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Article

Metabolic control of antifungal drug resistance.

Fungal genetics and biology : FG & B - 1 Feb 2010

Robbins Nicole, Collins Cathy, Morhayim Jess, Cowen Leah E

Abstract excerpt

Fungi have evolved an elegant repertoire of mechanisms to survive the cellular stress exerted by antifungal drugs such as azoles, which inhibit ergosterol biosynthesis inducing cell membrane stress. The evolution and maintenance of diverse resistance phenotypes is contingent upon cellular circuitry regulated by the molecular chaperone Hsp90 and its client protein calcineurin. Here, we establish a novel role for...

Topics

Amino Acids
Antifungal Agents
Azoles
Basic-Leucine Zipper Transcription Factors
Calcineurin
Culture Media
Drug Resistance, Fungal
Gene Expression
Genome, Fungal
HSP90 Heat-Shock Proteins
Microbial Sensitivity Tests

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Oxidoreductases

Phenotype

Reverse Transcriptase Polymerase Chain Reaction

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 19595784
DOI: 10.1016/j.fgb.2009.07.004

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