Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Metabolic control of antifungal drug resistance.

Fungal genetics and biology : FG & B - 1 Feb 2010

Robbins Nicole, Collins Cathy, Morhayim Jess, Cowen Leah E

Abstract excerpt

Fungi have evolved an elegant repertoire of mechanisms to survive the cellular stress exerted by antifungal drugs such as azoles, which inhibit ergosterol biosynthesis inducing cell membrane stress. The evolution and maintenance of diverse resistance phenotypes is contingent upon cellular circuitry regulated by the molecular chaperone Hsp90 and its client protein calcineurin. Here, we establish a novel role for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antifungal Agents
Share to Azoles
Share to Basic-Leucine Zipper Transcription Factors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Calcineurin

Share to Drug Resistance, Fungal

Share to Genome, Fungal

Share to HSP90 Heat-Shock Proteins

Share to Sirolimus

Source

Identifiers

PMID: 19595784
DOI: 10.1016/j.fgb.2009.07.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Metabolic control of antifungal drug resistance.PMID 19595784Read ↗

Global analysis of genetic circuitry and adaptive mechanisms enabling resistance to the azole antifungal drugs.Semantic proximity Read ↗

Genetic and Genomic Architecture of the Evolution of Resistance to Antifungal Drug CombinationsSemantic proximity Read ↗

Genetic architecture of Hsp90-dependent drug resistance.Semantic proximity Read ↗

Mapping the Hsp90 Genetic Network Reveals Ergosterol Biosynthesis and Phosphatidylinositol-4-Kinase Signaling as Core Circuitry Governing Cellular StressSemantic proximity Read ↗

Erg251 has complex and pleiotropic effects on sterol composition, azole susceptibility, filamentation, and stress response phenotypes.Semantic proximity Read ↗

Erg251 has complex and pleiotropic effects on azole susceptibility, filamentation, and stress response phenotypesSemantic proximity Read ↗

Molecular mechanisms of azole resistance in fungiSemantic proximity Read ↗

Magnesium deprivation affects cellular circuitry involved in drug resistance and virulence in Candida albicansSemantic proximity Read ↗

Redefining pleiotropic drug resistance in a pathogenic yeast: Pdr1 functions as a sensor of cellular stresses in Candida glabrataSemantic proximity Read ↗

Fitness Trade-Offs Associated with the Evolution of Resistance to Antifungal Drug CombinationsSemantic proximity Read ↗

Most azole resistance mutations in the Candida albicans drug target confer cross-resistance without intrinsic fitness cost.Semantic proximity Read ↗

Mitochondrial dysfunctions trigger the calcium signaling-dependent fungal multidrug resistanceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.