Article
Immunological tolerance to a pancreatic antigen as a result of local expression of TNFalpha by islet beta cells.
Immunity - 1 Sept 1997
McSorley S J, Soldera S, Malherbe L, Carnaud C, Locksley R M, Flavell R A, Glaichenhaus N
Abstract excerpt
Recent experiments have suggested that tumor necrosis factor alpha (TNFalpha) can down-regulate islet-specific T cells and prevent the development of autoimmune diabetes. Here we demonstrate that transgenic mice expressing both TNFalpha and the Leishmania major LACK antigen in the pancreas (RIP-TNFalpha/RIP-LACK) exhibit an impaired ability to mount a CD4+ T cell response against LACK. In addition, peripheral...
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