Absence of K-ras mutations in the pancreatic parenchyma of patients with chronic pancreatitis.

doi:10.1016/s0002-9610(97)00133-5

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Article

Absence of K-ras mutations in the pancreatic parenchyma of patients with chronic pancreatitis.

American journal of surgery - 1 Sept 1997

Hsiang D, Friess H, Büchler M W, Ebert M, Butler J, Korc M

Abstract excerpt

BACKGROUND: Human pancreatic cancers exhibit a high frequency of K-ras mutations. METHODS: In this study we used oligonucleotide specific hybridization to compare the frequency of K-ras mutations in genomic DNA samples prepared from 21 normal pancreatic tissues, 26 chronic pancreatitis tissues, a...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Chronic Disease
DNA, Neoplasm
Female
Genes, ras
Humans
Male
Middle Aged
Mutation
Pancreas
Pancreatitis
Tumor Cells, Cultured

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