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Article

Sheepish B cells: evidence for antigen-independent antibody diversification in humans and mice.

The Journal of experimental medicine - 9 Jun 2008

Tarlinton David

Abstract excerpt

Antibody diversity is first generated by rearrangement of immunoglobulin (Ig) genes during B cell development in the bone marrow, and later by antigen-driven diversification in germinal centers (GCs). New data in humans and mice now identify specific B cell populations that may have undergone antigen-independent hypermutation outside GCs.

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Share to Antibodies
Share to Antigen-Antibody Complex
Share to B-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Rearrangement, B-Lymphocyte

Share to Genes, Immunoglobulin

Share to Receptors, Antigen, B-Cell

Share to Species Specificity

Source

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Identifiers

PMID: 18519651
DOI: 10.1084/jem.20081057
PMCID: PMC2413022

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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