Article
Comparative effects of indapamide and hydrochlorothiazide on cardiac hypertrophy and vascular smooth-muscle phenotype in the stroke-prone, spontaneously hypertensive rat.
Journal of cardiovascular pharmacology - 1 Jan 1993
Contard F, Glukhova M, Sabri A, Marotte F, Sartore S, Narcisse G, Schatz C, Guez D, Rappaport L, Samuel J L
Abstract excerpt
The effects of two diuretics, indapamide (3 mg/kg/day) and hydrochlorothiazide (20 mg/kg/day), were analyzed over a 44-day period on the cardiovascular hypertrophy of stroke-prone spontaneously hypertensive rats (SHR-SP). Untreated SHR-SP developed severe hypertension and cardiac hypertrophy when compared to normotensive Wistar-Kyoto (WKY) rats after 8 weeks on 1% sodium chloride. In diuretic-treated animals,...
Topics
- Animals
- Blood Pressure
- Cardiomegaly
- Coronary Vessels
- Hydrochlorothiazide
- Hypertension
- Indapamide
- Male
- Muscle Contraction
- Muscle, Smooth, Vascular