Article
Survival of a bacterioferritin deletion mutant of Brucella melitensis 16M in human monocyte-derived macrophages.
Infection and immunity - 1 Oct 1997
Denoel P A, Crawford R M, Zygmunt M S, Tibor A, Weynants V E, Godfroid F, Hoover D L, Letesson J J
Abstract excerpt
A bacterioferritin (BFR) deletion mutant of Brucella melitensis 16M was generated by gene replacement. The deletion was complemented with a broad-host-range vector carrying the wild-type bfr gene, pBBR-bfr. The survival and growth of the mutant, B. melitensis PAD 2-78, were similar to those of its parental strain in human monocyte-derived macrophages (MDM). These results suggest that BFR is not essential for the...
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