Article
Survival of a bacterioferritin deletion mutant of Brucella melitensis 16M in human monocyte-derived macrophages.
Infection and immunity - 1 Oct 1997
Denoel P A, Crawford R M, Zygmunt M S, Tibor A, Weynants V E, Godfroid F, Hoover D L, Letesson J J
Abstract excerpt
A bacterioferritin (BFR) deletion mutant of Brucella melitensis 16M was generated by gene replacement. The deletion was complemented with a broad-host-range vector carrying the wild-type bfr gene, pBBR-bfr. The survival and growth of the mutant, B. melitensis PAD 2-78, were similar to those of it...
Topics
- Bacterial Proteins
- Brucella melitensis
- Cytochrome b Group
- Ferritins
- Gene Deletion
- Genetic Complementation Test
- Humans
- Macrophages
- Monocytes
- Mutation
- Oxidative Stress
- Species Specificity