Article
T Cell Immunity to the Alkyl Hydroperoxide Reductase of Burkholderia pseudomallei: A Correlate of Disease Outcome in Acute Melioidosis.
Journal of immunology (Baltimore, Md. : 1950) - 15 May 2015
Reynolds Catherine, Goudet Amélie, Jenjaroen Kemajittra, Sumonwiriya Manutsanun, Rinchai Darawan, Musson Julie, Overbeek Saskia, Makinde Julia, Quigley Kathryn, Manji Jiten, Spink Natasha, Yos Pagnarith, Wuthiekanun Vanaporn, Bancroft Gregory, Robinson John, Lertmemongkolchai Ganjana, Dunachie Susanna, Maillere Bernard, Holden Matthew, Altmann Daniel, Boyton Rosemary
Abstract excerpt
There is an urgent need for a better understanding of adaptive immunity to Burkholderia pseudomallei, the causative agent of melioidosis that is frequently associated with sepsis or death in patients in Southeast Asia and Northern Australia. The imperative to identify vaccine targets is driven both by the public health agenda in these regions and biological threat concerns. In several intracellular bacterial...
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