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Article

Proline isomerization of histone H3 regulates lysine methylation and gene expression.

Cell - 8 Sept 2006

Nelson Christopher J, Santos-Rosa Helena, Kouzarides Tony

Abstract excerpt

The cis-trans isomerization of proline serves as a regulatory switch in signaling pathways. We identify the proline isomerase Fpr4, a member of the FK506 binding protein family in Saccharomyces cerevisiae, as an enzyme which binds the amino-terminal tail of histones H3 and H4 and catalyses the isomerization of H3 proline P30 and P38 in vitro. We show that P38 is necessary for methylation of K36 and that...

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Identifiers

PMID: 16959570
DOI: 10.1016/j.cell.2006.07.026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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