Article
A mutation in the myostatin gene increases muscle mass and enhances racing performance in heterozygote dogs.
PLoS genetics - 25 May 2007
Mosher Dana S, Quignon Pascale, Bustamante Carlos D, Sutter Nathan B, Mellersh Cathryn S, Parker Heidi G, Ostrander Elaine A
Abstract excerpt
Double muscling is a trait previously described in several mammalian species including cattle and sheep and is caused by mutations in the myostatin (MSTN) gene (previously referred to as GDF8). Here we describe a new mutation in MSTN found in the whippet dog breed that results in a double-muscled phenotype known as the "bully" whippet. Individuals with this phenotype carry two copies of a two-base-pair deletion...
Topics
- Animals
- Base Pairing
- Base Sequence
- Breeding
- DNA Mutational Analysis
- Dogs
- Haplotypes
- Heterozygote
- Inheritance Patterns
- Molecular Sequence Data
- Muscle, Skeletal