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Synthesis of infectious human papillomavirus type 18 in differentiating epithelium transfected with viral DNA

1 Oct 1997

Abstract excerpt

The lack of a permissive system for the propagation of viral stocks containing abundant human papillomavirus (HPV) particles has hindered the study of infectivity and the early stages of HPV replication. The organotypic (raft) culture system has permitted the study of a number of the differentiation-specific aspects of HPV, including amplification of viral DNA, expression of late genes, and viral morphogenesis....

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PMID: 9311816
DOI: 10.1128/jvi.71.10.7381-7386.1997

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