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Article

Biosynthesis of Human Papillomavirus from a Continuous Cell Line Upon Epithelial Differentiation

14 Aug 1992

Abstract excerpt

The study of the human pathogen papillomaviruses (HPVs) has been hampered by the inability to propagate the virus in tissue culture. The addition of 12-O-tetradecanoyl phorbol-13-acetate to the media of organotypic (raft) cultures increased expression of physiological markers of keratinocyte differentiation and concomitantly induced production of virions. Capsid production was detected in differentiated...

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PMID: 1323879
DOI: 10.1126/science.1323879

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