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Amplification of human papillomavirus genomes in vitro is dependent on epithelial differentiation

1 May 1991

Abstract excerpt

Human papillomaviruses (HPVs) infect squamous epithelium and establish their genomes as episomes in proliferating basal cells. As infected cells differentiate, the viral DNA is amplified to high copy number and infectious virus is produced. Viral production has not yet been observed in vitro due to the inability of standard culture methods to duplicate most stages of epithelial differentiation. In this study, we...

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PMID: 1850010
DOI: 10.1128/jvi.65.5.2254-2260.1991

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