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A new cell culture model to genetically dissect the complete human papillomavirus life cycle

1 Mar 2018

Abstract excerpt

Herein, we describe a novel infection model that achieves highly efficient infection of primary keratinocytes with human papillomavirus type 16 (HPV16). This cell culture model does not depend on immortalization and is amenable to extensive genetic analyses. In monolayer cell culture, the early but not late promoter was active and yielded a spliced viral transcript pattern similar to HPV16-immortalized...

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PMID: 29494681
DOI: 10.1371/journal.ppat.1006846

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