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Infectious human papillomavirus type 31b: purification and infection of an immortalized human keratinocyte cell line

1 Nov 2002

Abstract excerpt

Human papillomaviruses (HPVs) are aetiological agents of human malignancies, most notably cervical cancers. The life-cycles of HPVs are dependent on epithelial differentiation, and this has impeded many basic studies of HPV biology. The organotypic (raft) culture system supports epithelial differentiation such that infectious virions are synthesized in raft tissues from epithelial cells that replicate...

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PMID: 12388811
DOI: 10.1099/0022-1317-83-11-2753

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