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Targeted Gene Therapy for Mutated H-ras and C-raf.1 Genes Exhibited Variable Efficacy in Inhibiting Hepatocellular Carcinoma in Rats: A Mechanistic Approach.

Pharmaceutical research - 1 Mar 2026

Mukherjee Alankar, Chakraborty Samrat, Sen Ramkrishna, Chandra Rima, Gope Srijita, Giri Tapan Kumar, Mukherjee Biswajit

Abstract excerpt

OBJECTIVE: Mutated H-ras or c-raf.1 gene expressions are often associated with HCC development and progression. Using intravenous administration of respective backbone modified antisense oligomer (ASO) in chemically induced HCC rats, we tried to understand the efficacy and mechanistic intervention of the treatments. METHODS: ASO-mediated in vitro cell cytotoxicity, cellular apoptosis, and alteration of...

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Share to Carcinoma, Hepatocellular
Share to Genes, ras

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hep G2 Cells

Share to Liver Neoplasms, Experimental

Share to Membrane Potential, Mitochondrial

Share to Oligonucleotides, Antisense

Share to Proto-Oncogene Proteins c-raf

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Identifiers

PMID: 41721069
DOI: 10.1007/s11095-026-04034-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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