Article
Oligonucleotide treatment of ras-induced tumors in nude mice.
Molecular biotechnology - 1 May 2001
Wickstrom E
Abstract excerpt
Oligonucleotides have shown an ability to target specific oncogene transcripts and inhibit their expression in cells, but the degree to which sustained treatment can suppress the levels of an oncogenic protein enough to benefit a patient remains to be determined. This question has been studied in several ways. First, the relationship of antisense DNA inhibition to the predicted secondary structure of human H-RAS...
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