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Article

Constitutively active Galphaq and Galpha13 trigger apoptosis through different pathways.

The Journal of biological chemistry - 26 Sept 1997

Althoefer H, Eversole-Cire P, Simon M I

Abstract excerpt

We investigated the effect of expression of constitutively active Galpha mutants on cell survival. Transfection of constitutively active Galphaq and Galpha13 in two different cell lines caused condensation of genomic DNA and nuclear fragmentation. Endonuclease cleavage of genomic DNA was followed by labeling the DNA fragments and subsequent flow cytometric analysis. The observed cellular phenotype was identical...

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Identifiers

PMID: 9305896
DOI: 10.1074/jbc.272.39.24380

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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