Article
A small region in phosducin inhibits G-protein betagamma-subunit function.
The EMBO journal - 15 Aug 1997
Blüml K, Schnepp W, Schröder S, Beyermann M, Macias M, Oschkinat H, Lohse M J
Abstract excerpt
G-protein betagamma-subunits (G(betagamma)) are active transmembrane signalling components. Their function recently has been observed to be regulated by the cytosolic protein phosducin. We show here that a small fragment (amino acids 215-232) contained in the C-terminus of phosducin is sufficient for high-affinity interactions with G(betagamma). Corresponding peptides not only disrupt G(betagamma)-G(alpha)...
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