Article
Chromosome changes in human cancer--are they pointers to mechanisms of initiation?
Radiation oncology investigations - 1 Jan 1997
Tawn E J
Abstract excerpt
The identification of tumour-specific chromosome abnormalities in a wide range of malignancies together with an understanding of their role in the activation of proto-oncogenes and loss of tumour suppressor genes has resulted in chromosome analysis of malignant cells beginning to provide information on the etiology of different malignancies. Two principle types of translocation have been identified. In the first,...
Topics
- Alleles
- Chimera
- Chromosome Aberrations
- Chromosome Breakage
- Chromosome Deletion
- Chromosome Disorders
- Chromosomes
- Enhancer Elements, Genetic
- Gene Expression Regulation, Neoplastic
- Genes, Immunoglobulin
- Genes, Tumor Suppressor