Mechanisms for induction of mutations and chromosome alterations.

Abstract excerpt

Genotoxic agents induce chromosomal alterations, such as aberrations, micronuclei, and sister chromatid exchanges as well as mutations both in vivo and in vitro. Ionizing radiation and typical radiomimmetic agents such as bleomycin are very efficient inducers of chromosomal aberrations. The type of aberrations induced by these agents are cell-cycle dependent, i.e., chromosome type in pre-replication stages and...

Topics

• Chromosome Aberrations
• Humans
• Lymphocytes
• Micronuclei, Chromosome-Defective
• Mutagens
• Mutation
• Sister Chromatid Exchange