Chromosomal rearrangement as the basis for human tumourigenesis.

Abstract excerpt

PURPOSE: To develop a model for the initiation of human tumourigenesis that is consistent with various observations that are difficult to reconcile with current models. CONCLUSIONS: A novel model of tumourigenesis was developed that includes three basic postulates: (1) tumourigenesis is initiated by recombinogenic DNA lesions, (2) potentially recombinogenic DNA lesions in transcribed regions of the genome can be...

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