Article
Radiation-induced chromatid breaks and deficient DNA repair in cancer predisposition.
Critical reviews in oncology/hematology - 1 Feb 2001
Parshad R, Sanford K K
Abstract excerpt
Deficient repair of DNA double-strand breaks, resulting in an abnormally high frequency of chromatid breaks after G(2) exposure of cells to radiation, appears to be associated with cancer predisposition. Unrepaired DNA strand breaks contribute to genomic instability. Unrepaired chromatid breaks representing DNA strand breaks can result in chromosome deletions, translocations and gene amplifications seen in human...
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