Article
Limb initiation and development is normal in the absence of the mesonephros.
Developmental biology - 15 Sept 1997
Fernandez-Teran M, Piedra M E, Simandl B K, Fallon J F, Ros M A
Abstract excerpt
With rapid progress in understanding the genes that control limb development and patterning interest is becoming focused on the factors that permit the emergence of the limb bud. The current hypothesis is that FGF-8 from the mesonephros induces limb initiation. To test this, the inductive interaction between the Wolffian duct and intermediate mesoderm was blocked rostral to the limb field, preventing mesonephric...
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