Regulation of p21WAF1/CIP1 expression through mitogen-activated protein kinase signaling pathway.

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Article

Regulation of p21WAF1/CIP1 expression through mitogen-activated protein kinase signaling pathway.

Cancer research - 1 Jan 1996

Liu Y, Martindale J L, Gorospe M, Holbrook N J

Abstract excerpt

p21WAF1/CIP1 is a cyclin-dependent kinase inhibitor whose expression in mammalian tissues is highly induced in response to stress as well as during normal development and differentiation. Induction of p21WAF1/CIP1 in response to DNA damage occurs through a transcriptional mechanism that is depend...

Topics

Animals
Base Sequence
Calcium-Calmodulin-Dependent Protein Kinases
Cyclin-Dependent Kinase Inhibitor p21
Cyclins
Gene Expression Regulation
Gene Transfer Techniques
Genes, Dominant
Genes, Recessive
HeLa Cells
Humans
Mitogens
Molecular Sequence Data
Mutation
PC12 Cells
RNA, Messenger
Rats
Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 8548769

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8548769-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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