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Article

BRCA1 modulates malignant cell behavior, the expression of survivin and chemosensitivity in human breast cancer cells

23 Jun 2009

Abstract excerpt

BRCA1 is a multifunctional tumor-suppressive protein. Many functional aspects of BRCA1 are not fully understood. We used a shRNA approach to probe the function of BRCA1 in human breast cancer cells. Knocking down BRCA1 expression by shRNA in the wild-type BRCA1 human breast cancer MCF-7 and MDA-MB-231 cells resulted in an increase in cell proliferation, anchorage-independent growth, cell migration, invasion and a...

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PMID: 19551867
DOI: 10.1002/ijc.24684

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