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Article

Oxidative Damage of Proteins Precedes Loss of Cholinergic Phenotype in the Septal Neurons of Olfactory Bulbectomized Mice.

Current Alzheimer research - 1 Jan 2021

Nedogreeva O A, Evtushenko N A, Manolova A O, Peregud D I, Yakovlev A A, Lazareva N A, Gulyaeva N V, Stepanichev M Y

Abstract excerpt

BACKGROUND: The development of cholinergic deficit is considered an early sign of a number of pathological conditions, including Alzheimer's disease. Cholinergic dysfunction underlies cognitive decline associated with both normal aging and Alzheimer's disease. OBJECTIVE: Here, we studied a possible mechanism of functional impairment of cholinergic neurons using an olfactory bulbectomy model. METHODS: Male mice...

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Identifiers

PMID: 34951385
DOI: 10.2174/1567205019666211223094051

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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