Article
Plasminogen deficiency accelerates vessel wall disease in mice predisposed to atherosclerosis.
Proceedings of the National Academy of Sciences of the United States of America - 16 Sept 1997
Xiao Q, Danton M J, Witte D P, Kowala M C, Valentine M T, Bugge T H, Degen J L
Abstract excerpt
A critical link between hemostatic factors and atherosclerosis has been inferred from a variety of indirect observations, including the expression of procoagulant and fibrinolytic factors within atherosclerotic vessels, the presence of fibrin in intimal lesions, and the cellular infiltration of mural thrombi leading to their incorporation into developing plaques. To directly examine the role of the key...
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