Article
Reconstitution of mutant V2 vasopressin receptors by adenovirus-mediated gene transfer. Molecular basis and clinical implication.
The Journal of clinical investigation - 15 Sept 1997
Schöneberg T, Sandig V, Wess J, Gudermann T, Schultz G
Abstract excerpt
Recent studies with transfected COS-7 cells have shown that functionally inactive mutant V2 vasopressin receptors (occurring in patients with nephrogenic diabetes insipidus) can be functionally rescued by coexpression of a carboxy-terminal V2 receptor fragment (V2-tail) spanning the region where...
Topics
- Adenoviridae
- Animals
- Arginine Vasopressin
- CHO Cells
- Cell Line
- Cholecystokinin
- Cricetinae
- Cyclic AMP
- Dogs
- Enzyme-Linked Immunosorbent Assay
- Fluorescent Antibody Technique, Indirect
- Gene Expression
- Gene Transfer Techniques
- Genetic Vectors
- Gonadotropin-Releasing Hormone
- Kidney Tubules
- Luteinizing Hormone
- Mutation