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Article

Reconstitution of mutant V2 vasopressin receptors by adenovirus-mediated gene transfer. Molecular basis and clinical implication.

The Journal of clinical investigation - 15 Sept 1997

Schöneberg T, Sandig V, Wess J, Gudermann T, Schultz G

Abstract excerpt

Recent studies with transfected COS-7 cells have shown that functionally inactive mutant V2 vasopressin receptors (occurring in patients with nephrogenic diabetes insipidus) can be functionally rescued by coexpression of a carboxy-terminal V2 receptor fragment (V2-tail) spanning the region where various mutations occur [Schöneberg, T., J. Yun, D. Wenkert, and J. Wess. 1996. EMBO (Eur. Mol. Biol. Organ.) J....

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Identifiers

PMID: 9294123
DOI: 10.1172/JCI119678
PMCID: PMC508336

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Reconstitution of mutant V2 vasopressin receptors by adenovirus-mediated gene transfer. Molecular basis and clinical implication.PMID 9294123Read ↗

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Pharmacological chaperones in nephrogenic diabetes insipidus: possibilities for clinical application.Semantic proximity Read ↗

Adeno-associated Virus (AAV) Serotypes Have Distinctive Interactions with Domains of the Cellular AAV ReceptorSemantic proximity Read ↗

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