Article
Functional rescue of mutant V2 vasopressin receptors causing nephrogenic diabetes insipidus by a co-expressed receptor polypeptide.
The EMBO journal - 15 Mar 1996
Schoneberg T, Yun J, Wenkert D, Wess J
Abstract excerpt
Inactivating mutations in distinct G protein-coupled receptors (GPCRs) are currently being identified as the cause of a steadily growing number of human diseases. Based on previous studies showing that GPCRs are assembled from multiple independently stable folding units, we speculated that such m...
Topics
- Amino Acid Sequence
- Arginine Vasopressin
- Binding Sites
- Biological Transport
- Cell Compartmentation
- Cyclic AMP
- Diabetes Insipidus, Nephrogenic
- Dose-Response Relationship, Drug
- Fluorescent Antibody Technique
- GTP-Binding Proteins
- Humans
- Molecular Sequence Data
- Mutation
- Peptide Fragments
- Receptors, Vasopressin
- Recombinant Proteins
- Signal Transduction