Article
Pharmacochaperones post-translationally enhance cell surface expression by increasing conformational stability of wild-type and mutant vasopressin V2 receptors.
The Journal of biological chemistry - 5 Nov 2004
Wüller Stefan, Wiesner Burkhard, Löffler Anja, Furkert Jens, Krause Gerd, Hermosilla Ricardo, Schaefer Michael, Schülein Ralf, Rosenthal Walter, Oksche Alexander
Abstract excerpt
Some membrane-permeable antagonists restore cell surface expression of misfolded receptors retained in the endoplasmic reticulum (ER) and are therefore termed pharmacochaperones. Whether pharmacochaperones increase protein stability, thereby preventing rapid degradation, or assist folding via direct receptor interactions or interfere with quality control components remains elusive. We now show that the cell...
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