Vasopressin receptors and pharmacological chaperones: from functional rescue to promising therapeutic strategies.

Abstract excerpt

Conformational diseases result from protein misfolding and/or aggregation and constitute a major public health problem. Congenital Nephrogenic Diabetes Insipidus is a typical conformational disease. In most of the cases, it is associated to inactivating mutations of the renal arginine-vasopressin V2 receptor gene leading to misfolding and intracellular retention of the receptor, causing the inability of patients...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Diabetes Insipidus, Nephrogenic
• Share to Drug Discovery
• Share to Mutation