Article
Molecular genetic studies in medulloblastomas: evidence for tumor suppressor genes at the chromosomal regions 1q31-32 and 17p13.
Klinische Padiatrie - 1 Jan 2000
Pietsch T, Koch A, Wiestler O D
Abstract excerpt
BACKGROUND: Medulloblastoma represents a common primitive neuroectodermal tumor of the cerebellum, the molecular pathogenesis of which has not been identified. Previous cytogenetic observations disclosed aberrations of chromosome 1 and 17 in medulloblastomas. In the present study, we have molecul...
Topics
- Adolescent
- Adult
- Alleles
- Cerebellar Neoplasms
- Child
- Child, Preschool
- Chromosome Deletion
- Chromosome Mapping
- Chromosomes, Human, Pair 1
- Chromosomes, Human, Pair 17
- Female
- Genes, Tumor Suppressor
- Humans
- Male
- Medulloblastoma
- Microsatellite Repeats
- Middle Aged
- Molecular Biology