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Article

Transactivation of Igf2 in a mouse model of Beckwith-Wiedemann syndrome.

Nature - 23 Oct 1997

Sun F L, Dean W L, Kelsey G, Allen N D, Reik W

Abstract excerpt

The gene IGF2, which encodes a fetal insulin-like growth factor, is imprinted, so only one of two parental copies of the gene is expressed. The altered expression of IGF2 has been implicated in Beckwith-Wiedemann syndrome, a human fetal overgrowth syndrome, which is characterized by overgrowth of several organs and an increased risk of developing childhood tumours. We have introduced Igf2 transgenes into the...

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Source

Identifiers

PMID: 9349812
DOI: 10.1038/39797

Genes

IGF2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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