Article
Transactivation of Igf2 in a mouse model of Beckwith-Wiedemann syndrome.
Nature - 23 Oct 1997
Sun F L, Dean W L, Kelsey G, Allen N D, Reik W
Abstract excerpt
The gene IGF2, which encodes a fetal insulin-like growth factor, is imprinted, so only one of two parental copies of the gene is expressed. The altered expression of IGF2 has been implicated in Beckwith-Wiedemann syndrome, a human fetal overgrowth syndrome, which is characterized by overgrowth of...
Topics
- Animals
- Animals, Newborn
- Beckwith-Wiedemann Syndrome
- Cell Line
- Chimera
- DNA Methylation
- Disease Models, Animal
- Embryonic and Fetal Development
- Gene Expression Regulation, Developmental
- Genomic Imprinting
- Humans
- Insulin-Like Growth Factor II