Article
Systematic screening of chromosome 18 for loss of heterozygosity in esophageal squamous cell carcinoma.
Cancer genetics and cytogenetics - 1 May 1999
Karkera J D, Balan K V, Yoshikawa T, Lipman T O, Korman L, Sharma A, Patterson R H, Sani N, Detera-Wadleigh S D, Wadleigh R G
Abstract excerpt
Esophageal cancer ranks among the 10 most common cancers in the world, and is almost uniformly fatal. The genetic events leading to the development of esophageal carcinoma are not well established. To identify genomic regions involved in esophageal carcinogenesis, we performed a systematic screening for loss of heterozygosity (LOH) in 24 samples of squamous cell carcinomas, initially focusing the analysis on...
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