Article
The amino-terminal domain of CCR2 is both necessary and sufficient for high affinity binding of monocyte chemoattractant protein 1. Receptor activation by a pseudo-tethered ligand.
The Journal of biological chemistry - 12 Sept 1997
Monteclaro F S, Charo I F
Abstract excerpt
High affinity binding of monocyte chemoattractant protein 1 (MCP-1) requires the presence of the amino-terminal domain of CCR2, the MCP-1 receptor. Here we report that the 35 amino-terminal residues of CCR2, expressed as a membrane-bound fusion protein, bound MCP-1 with an affinity similar to tha...
Topics
- Adenylyl Cyclase Inhibitors
- Chemokine CCL2
- Cysteine
- Models, Molecular
- Mutation
- Peptide Fragments
- Protein Binding
- Receptors, CCR2
- Receptors, Chemokine
- Receptors, Cytokine
- Recombinant Fusion Proteins
- Signal Transduction