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Article

Spy1 Interacts with p27Kip1 to Allow G1/S Progression

14 Jul 2003

Abstract excerpt

Progression through the G1/S transition commits cells to synthesize DNA. Cyclin dependent kinase 2 (CDK2) is the major kinase that allows progression through G1/S phase and subsequent replication events. p27 is a CDK inhibitor (CKI) that binds to CDK2 to prevent premature activation of this kinase. Speedy (Spy1), a novel cell cycle regulatory protein, has been found to prematurely activate CDK2 when microinjected...

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Identifiers

PMID: 12972555
DOI: 10.1091/mbc.e02-12-0820

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Spy1 Interacts with p27Kip1 to Allow G1/S ProgressionPMID 12972555Read ↗

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