Article
The yeast ser/thr phosphatases sit4 and ppz1 play opposite roles in regulation of the cell cycle.
Molecular and cellular biology - 1 Mar 1999
Clotet J, Garí E, Aldea M, Ariño J
Abstract excerpt
Yeast cells overexpressing the Ser/Thr protein phosphatase Ppz1 display a slow-growth phenotype. These cells recover slowly from alpha-factor or nutrient depletion-induced G1 arrest, showing a considerable delay in bud emergence as well as in the expression of the G1 cyclins Cln2 and Clb5. Therefore, an excess of the Ppz1 phosphatase interferes with the normal transition from G1 to S phase. The growth defect is...
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