Article
Lack of evidence for a major locus for bipolar disorder in the pericentromeric region of chromosome 18 in Irish pedigrees.
Biological psychiatry - 15 Sept 1997
Mynett-Johnson L A, Murphy V E, Manley P, Shields D C, McKeon P
Abstract excerpt
Seven families, multiply affected by bipolar mood disorder, have been collected from the Irish population and have been genotyped with microsatellite markers from the pericentromeric region of chromosome 18, a region that has been implicated as a site for a susceptibility gene for this relative common psychiatric disorder. The families significantly excluded linkage of bipolar disorder to this region under...
Topics
- Adult
- Bipolar Disorder
- Chromosomes, Human, Pair 18
- Female
- Genetic Linkage
- Genotype
- Humans
- Ireland
- Male
- Microsatellite Repeats
- Models, Genetic