Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Full-genome scan for linkage in 50 families segregating the bipolar affective disease phenotype.

American journal of human genetics - 1 Jan 2000

Friddle C, Koskela R, Ranade K, Hebert J, Cargill M, Clark C D, McInnis M, Simpson S, McMahon F, Stine O C, Meyers D, Xu J, MacKinnon D, Swift-Scanlan T, Jamison K, Folstein S, Daly M, Kruglyak L, Marr T, DePaulo J R, Botstein D

Abstract excerpt

A genome scan of approximately 12-cM initial resolution was done on 50 of a set of 51 carefully ascertained unilineal multiplex families segregating the bipolar affective disorder phenotype. In addition to standard multipoint linkage analysis methods, a simultaneous-search algorithm was applied in an attempt to surmount the problem of genetic heterogeneity. The results revealed no linkage across the genome. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Models, Genetic
Share to Bipolar Disorder

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genome, Human

Share to Lod Score

Share to Pedigree

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 10631152
DOI: 10.1086/302697
PMCID: PMC1288327

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Full-genome scan for linkage in 50 families segregating the bipolar affective disease phenotype.PMID 10631152Read ↗

Genome scans for susceptibility genes in bipolar affective disorder.Semantic proximity Read ↗

The Wellcome trust UK-Irish bipolar affective disorder sibling-pair genome screen: first stage report.Semantic proximity Read ↗

Genome wide scan using homozygosity mapping and linkage analyses of a single pedigree with affective disorder suggests oligogenic inheritance.Semantic proximity Read ↗

Genome-wide linkage analysis of 972 bipolar pedigrees using single-nucleotide polymorphisms.Semantic proximity Read ↗

Scanning the genome with 1772 microsatellite markers in search of a bipolar disorder susceptibility gene.Semantic proximity Read ↗

A comprehensive linkage analysis of chromosome 21q22 supports prior evidence for a putative bipolar affective disorder locus.Semantic proximity Read ↗

Genome screen of 15 Australian bipolar affective disorder pedigrees supports previously identified loci for bipolar susceptibility genes.Semantic proximity Read ↗

A genome screen for genes predisposing to bipolar affective disorder detects a new susceptibility locus on 8q.Semantic proximity Read ↗

Genetic linkage and association studies in bipolar affective disorder: a time for optimism.Semantic proximity Read ↗

A possible susceptibility locus for bipolar affective disorder in chromosomal region 10q25--q26.Semantic proximity Read ↗

A genome-wide search for chromosomal loci linked to bipolar affective disorder in the Old Order Amish.Semantic proximity Read ↗

Genome-wide scan for genes involved in bipolar affective disorder in 70 European families ascertained through a bipolar type I early-onset proband: supportive evidence for linkage at 3p14.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.