Article
Pathogenesis of SIV encephalitis. Selection and replication of neurovirulent SIV.
The American journal of pathology - 1 Sept 1997
Zink M C, Amedee A M, Mankowski J L, Craig L, Didier P, Carter D L, Muñoz A, Murphey-Corb M, Clements J E
Abstract excerpt
To investigate the viral and host factors that contribute to neurological disease, nine macaques were intravenously co-inoculated with SIV/DeltaB670, a primary isolate of SIV consisting of at least 21 different genotypes, and SIV/17E-Fr, a neurovirulent recombinant clone. CD4+ cell counts and ant...
Topics
- Animals
- Brain
- CD4-Positive T-Lymphocytes
- Encephalitis
- Enzyme-Linked Immunosorbent Assay
- Female
- Gene Products, gag
- Genotype
- Histocytochemistry
- In Situ Hybridization
- Lymph Nodes
- Macaca
- Pregnancy
- RNA, Viral
- Simian Acquired Immunodeficiency Syndrome