Article
Increased prevalence of the seven-repeat variant of the dopamine D4 receptor gene in patients with obsessive-compulsive disorder with tics.
Neuroscience letters - 1 Aug 1997
Cruz C, Camarena B, King N, Páez F, Sidenberg D, de la Fuente J R, Nicolini H
Abstract excerpt
The polymorphism characterized by a varying number of 48 bp repeats (VNTR) in the dopamine D4 receptor (DRD4) gene was examined in 61 obsessive-compulsive disorder (OCD) probands with and without tics. Most of the OCD patients with tics showed at least one copy of the 7-fold variant compared to t...
Topics
- Alleles
- DNA
- Family Health
- Female
- Gene Frequency
- Genotype
- Humans
- Male
- Obsessive-Compulsive Disorder
- Receptors, Dopamine D2
- Receptors, Dopamine D4
- Repetitive Sequences, Nucleic Acid
- Tic Disorders
- Tourette Syndrome