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Article

Association study between the dopamine receptor D(4) gene and obsessive-compulsive disorder.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Jan 2000

Camarena Beatriz, Loyzaga Cristina, Aguilar Alejandro, Weissbecker Karen, Nicolini Humberto

Abstract excerpt

Pharmacological and neuroanatomical evidence suggest the involvement of the dopaminergic system in obsessive-compulsive disorder (OCD). Analysis of the 48-bp dopamine receptor D(4) (DRD4) gene polymorphism in a sample of 210 OCD patients and 202 healthy control subjects showed a significant association (chi(2)=27.5, df=6, p=0.0003). This difference was attributable to a lower frequency of allele 4R in OCD...

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Source

Identifiers

PMID: 16996722
DOI: 10.1016/j.euroneuro.2006.08.001

Genes

DRD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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