Association analysis of SLC6A4 and HTR2A genes with obsessive-compulsive disorder: Influence of the STin2 polymorphism.

doi:10.1016/j.comppsych.2017.12.004

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Article

Association analysis of SLC6A4 and HTR2A genes with obsessive-compulsive disorder: Influence of the STin2 polymorphism.

Comprehensive psychiatry - 1 Apr 2018

Gomes Chayenne Karine Ferreira, Vieira-Fonseca Tamiris, Melo-Felippe Fernanda Brito, de Salles Andrade Juliana Braga, Fontenelle Leonardo F, Kohlrausch Fabiana Barzotti

Abstract excerpt

BACKGROUND: Obsessive-Compulsive Disorder (OCD) is a complex and chronic disorder characterized by recurrent thoughts and/or repetitive behaviors. Given the potent anti-obsessional effects of the so-called serotonin reuptake inhibitors, genes related to serotonergic system may be well implicated in the etiopathogenesis of OCD. The gene encoding the serotonin transporter (SLC6A4), which shows a variable number of...

Topics

Adult
Brazil
Female
Genetic Association Studies
Genetic Predisposition to Disease
Humans
Male
Middle Aged
Obsessive-Compulsive Disorder
Polymorphism, Genetic
Receptor, Serotonin, 5-HT2A
Serotonin Plasma Membrane Transport Proteins

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Open in PubMed

Identifiers

PMID: 29331882
DOI: 10.1016/j.comppsych.2017.12.004

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