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Article

Possible carcinogenic effect of 6-mercaptopurine on bone marrow stem cells

15 Sept 1999

Abstract excerpt

BACKGROUND: 6-Mercaptopurine (6MP) has been regarded as nonleukemogenic, even though the cytotoxicity of 6MP depends on the incorporation of 6-thioguanine nucleotides (6TGN) into DNA. In hematopoietic cells this pathway competes with S-methylation catalyzed by thiopurine methyltransferase (TPMT). However, methylated 6MP metabolites inhibit purine de novo synthesis and thus may enhance incorporation of 6TGN into...

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Identifiers

PMID: 10491537
DOI: 10.1002/(sici)1097-0142(19990915)86:6<1080::aid-cncr26>3.0.co;2-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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