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Article

Effects of 6-thioguanine and S6-methylthioguanine on transcription in vitro and in human cells.

The Journal of biological chemistry - 30 Nov 2012

You Changjun, Dai Xiaoxia, Yuan Bifeng, Wang Yinsheng

Abstract excerpt

Thiopurine drugs are extensively used as chemotherapeutic agents in clinical practice, even though there is concern about the risk of therapy-related cancers. It has been previously suggested that the cytotoxicity of thiopurine drugs involves their metabolic activation, the resultant generation o...

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Identifiers

PMID: 23076150
DOI: 10.1074/jbc.M112.418681
PMCID: PMC3510796

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23076150-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Effects of 6-thioguanine and S6-methylthioguanine on transcription in vitro and in human cells.PMID 23076150Read ↗

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