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Article

Maintenance of the differentiated type II cell phenotype by culture with an apical air surface.

The American journal of physiology - 1 Aug 1997

Dobbs L G, Pian M S, Maglio M, Dumars S, Allen L

Abstract excerpt

The study of differentiated functions of alveolar type II cells has been hampered because of the lack of good in vitro systems. We report that culture of type II cells on collagen gels with an apical surface exposed to air promotes expression of differentiated type II cell characteristics. Cells...

Topics

Air
Animals
Biomarkers
Cell Differentiation
Cell Membrane
Cells, Cultured
Culture Media
Cytoskeletal Proteins
Germ-Free Life
Lung
Phenotype
Phosphatidylcholines
Plastics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pulmonary Surfactants

RNA, Messenger

Rats

Surface Properties

Source

Identifiers

PMID: 9277446
DOI: 10.1152/ajplung.1997.273.2.L347

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9277446-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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