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Article

Maintenance of the differentiated type II cell phenotype by culture with an apical air surface.

The American journal of physiology - 1 Aug 1997

Dobbs L G, Pian M S, Maglio M, Dumars S, Allen L

Abstract excerpt

The study of differentiated functions of alveolar type II cells has been hampered because of the lack of good in vitro systems. We report that culture of type II cells on collagen gels with an apical surface exposed to air promotes expression of differentiated type II cell characteristics. Cells cultured in this manner are cuboidal, contain lamellar bodies, and produce tubular myelin; in addition, they secrete...

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Identifiers

PMID: 9277446
DOI: 10.1152/ajplung.1997.273.2.L347

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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