Article
Regulated gene expression in cultured type II cells of adult human lung.
American journal of physiology. Lung cellular and molecular physiology - 1 Jul 2010
Ballard Philip L, Lee Jae W, Fang Xiaohui, Chapin Cheryl, Allen Lennell, Segal Mark R, Fischer Horst, Illek Beate, Gonzales Linda W, Kolla Venkatadri, Matthay Michael A
Abstract excerpt
Alveolar type II cells have multiple functions, including surfactant production and fluid clearance, which are critical for lung function. Differentiation of type II cells occurs in cultured fetal lung epithelial cells treated with dexamethasone plus cAMP and isobutylmethylxanthine (DCI) and involves increased expression of 388 genes. In this study, type II cells of human adult lung were isolated at approximately...
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