Sex-specific quantitative trait loci affecting longevity in Drosophila melanogaster.

doi:10.1073/pnas.94.18.9734

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Article

Sex-specific quantitative trait loci affecting longevity in Drosophila melanogaster.

Proceedings of the National Academy of Sciences of the United States of America - 2 Sept 1997

Nuzhdin S V, Pasyukova E G, Dilda C L, Zeng Z B, Mackay T F

Abstract excerpt

Senescence, the decline in survivorship and fertility with increasing age, is a near-universal property of organisms. Senescence and limited lifespan are thought to arise because weak natural selection late in life allows the accumulation of mutations with deleterious late-age effects that are either neutral (the mutation accumulation hypothesis) or beneficial (the antagonistic pleiotropy hypothesis) early in...

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PMID: 9275193
DOI: 10.1073/pnas.94.18.9734
PMCID: PMC23259

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.